New publication in JCI Insight!

📢HOT OFF THE PRESS!📢

Our latest study analyzes over 4,500 kidney transplant biopsies to explore how injury-associated gene expression—especially failed repair epithelial states—impacts long-term graft survival. We identified two distinct molecular dimensions of injury response:

🔹 PC1 – driven by acute/chronic injury, inflammation, and failed repair.
🔹 PC3 – linked to epithelial remodeling, independent of inflammation.

Both dimensions are significantly associated with future transplant failure, and their impact is amplified in older donor kidneys. Notably, we found that gene sets from failed repair epithelial cells in native kidneys performed as well as established transplant-derived markers in predicting outcomes.

📌 These insights may help refine our understanding of graft deterioration and guide future therapeutic strategies.

🔗: https://insight.jci.org/articles/view/188658